E-ISSN 2090-0503 | ISSN 1687-7497
 

Original Research 


Penicillial Hydroxamate Siderophore, Accelerates Wound Healing in Diabetic rats

Ravindran Sangeetha Kumari, Arumugam Ganesh, Karikalan Priyadharsini, Mohammed Riyaz.

Abstract
Fungal siderophores are less studied group of microorganisms with vast therapeutic potential. A hydroxamate siderophore has been derived and purified from P. chrysogenum NCIM707. This study investigated for wound healing activity of penicillial hydroxamate siderophore, preliminarily it was tested against five human pathogenic bacteria by disc diffusion and MTT assay. Antioxidant activity was determined by DPPH and H2O2 methods. Human pathogenic DNA cleavage was tested by agarose gel electrophoresis. Angiogenesis activity was evaluated with Chorio allantoic membrane (CAM) assay. Delayed in vivo wound healing was assessed with streptozotocin female Wistar-rats and, this study comprises to estimate hydroxyproline and collagen content in wounded tissue, gene expressions and histopathological analysis of wounded tissue. The hydroxamate siderophore (PHS) showed significant antioxidant, antimicrobial, angiogenic and wound healing capacity.

Key words: Chorio allantoic membrane (CAM) assay, DNA-cleavage, Hydroxamate siderophore, Hydroxyproline.


 
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How to Cite this Article
Pubmed Style

Kumari RS, Ganesh A, Priyadharsini K, Riyaz M, . Penicillial Hydroxamate Siderophore, Accelerates Wound Healing in Diabetic rats. Egypt. J. Exp. Biol. (Bot.). 2019; 15(1): 51-63. doi:10.5455/egyjebb.20181213110719


Web Style

Kumari RS, Ganesh A, Priyadharsini K, Riyaz M, . Penicillial Hydroxamate Siderophore, Accelerates Wound Healing in Diabetic rats. http://www.egyseb.net/?mno=21416 [Access: April 22, 2019]. doi:10.5455/egyjebb.20181213110719


AMA (American Medical Association) Style

Kumari RS, Ganesh A, Priyadharsini K, Riyaz M, . Penicillial Hydroxamate Siderophore, Accelerates Wound Healing in Diabetic rats. Egypt. J. Exp. Biol. (Bot.). 2019; 15(1): 51-63. doi:10.5455/egyjebb.20181213110719



Vancouver/ICMJE Style

Kumari RS, Ganesh A, Priyadharsini K, Riyaz M, . Penicillial Hydroxamate Siderophore, Accelerates Wound Healing in Diabetic rats. Egypt. J. Exp. Biol. (Bot.). (2019), [cited April 22, 2019]; 15(1): 51-63. doi:10.5455/egyjebb.20181213110719



Harvard Style

Kumari, R. . S., Ganesh, A. ., Priyadharsini, K. ., Riyaz, M. . & (2019) Penicillial Hydroxamate Siderophore, Accelerates Wound Healing in Diabetic rats. Egypt. J. Exp. Biol. (Bot.), 15 (1), 51-63. doi:10.5455/egyjebb.20181213110719



Turabian Style

Kumari, Ravindran Sangeetha, Arumugam Ganesh, Karikalan Priyadharsini, Mohammed Riyaz, and . 2019. Penicillial Hydroxamate Siderophore, Accelerates Wound Healing in Diabetic rats. THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany), 15 (1), 51-63. doi:10.5455/egyjebb.20181213110719



Chicago Style

Kumari, Ravindran Sangeetha, Arumugam Ganesh, Karikalan Priyadharsini, Mohammed Riyaz, and . "Penicillial Hydroxamate Siderophore, Accelerates Wound Healing in Diabetic rats." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany) 15 (2019), 51-63. doi:10.5455/egyjebb.20181213110719



MLA (The Modern Language Association) Style

Kumari, Ravindran Sangeetha, Arumugam Ganesh, Karikalan Priyadharsini, Mohammed Riyaz, and . "Penicillial Hydroxamate Siderophore, Accelerates Wound Healing in Diabetic rats." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany) 15.1 (2019), 51-63. Print. doi:10.5455/egyjebb.20181213110719



APA (American Psychological Association) Style

Kumari, R. . S., Ganesh, A. ., Priyadharsini, K. ., Riyaz, M. . & (2019) Penicillial Hydroxamate Siderophore, Accelerates Wound Healing in Diabetic rats. THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany), 15 (1), 51-63. doi:10.5455/egyjebb.20181213110719