E-ISSN 2090-0503 | ISSN 1687-7497
 

Original Research 


Antifungal Activity of Thymol Against Some Medically Important Fungi

Ghada K. Fath Allah, Adel A. El Mahalawy, Iman M. El Kholy, Samar S. Mohamed.

Abstract
Invasive fungal infections (IFIs) have emerged in the last three decades as an important cause of human disease. These infections treated particularly with triazole such as fluconazole, itraconazole and voriconazole but some serious adverse reactions have been reported in many studies. In vitro activities of 12 essential oils were evaluated against 6 clinically important fungi. Thyme oil was the most effective essential oil against all the tested fungi and Aspergillus flavus was the most susceptible with inhibition zone diameter and MIC value 39 mm and 0.25 µg/ml, respectively. Active ingredients of thyme oil were analyzed using GC/Mass chromatography and extracted by Thin Layer Chromatography (TLC). Thymol was the most active component against Aspergillus flavus with inhibition zone diameter and MIC value 44 mm and 0.125 µg/ml, respectively. The inhibitory activity of thymol against Aspergillus flavus was confirmed using Transmission electron microscope.

Key words: Thymol, Invasive fungal infections, Aspergillus flavus, GC/Mass, Essential oils, Antifungals, Thyme oil.


 
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How to Cite this Article
Pubmed Style

GKFA, AAEM, Kholy IME, Mohamed SS, . Antifungal Activity of Thymol Against Some Medically Important Fungi. Egypt. J. Exp. Biol. (Bot.). 2022; 18(1): 21-31. doi:10.5455/egyjebb.20220120025332


Web Style

GKFA, AAEM, Kholy IME, Mohamed SS, . Antifungal Activity of Thymol Against Some Medically Important Fungi. https://www.egyseb.net//?mno=11496 [Access: April 05, 2022]. doi:10.5455/egyjebb.20220120025332


AMA (American Medical Association) Style

GKFA, AAEM, Kholy IME, Mohamed SS, . Antifungal Activity of Thymol Against Some Medically Important Fungi. Egypt. J. Exp. Biol. (Bot.). 2022; 18(1): 21-31. doi:10.5455/egyjebb.20220120025332



Vancouver/ICMJE Style

GKFA, AAEM, Kholy IME, Mohamed SS, . Antifungal Activity of Thymol Against Some Medically Important Fungi. Egypt. J. Exp. Biol. (Bot.). (2022), [cited April 05, 2022]; 18(1): 21-31. doi:10.5455/egyjebb.20220120025332



Harvard Style

, G. K. F. A., , A. A. E. M., Kholy, I. M. E., Mohamed, S. S. & (2022) Antifungal Activity of Thymol Against Some Medically Important Fungi. Egypt. J. Exp. Biol. (Bot.), 18 (1), 21-31. doi:10.5455/egyjebb.20220120025332



Turabian Style

, Ghada K. Fath Allah, Adel A. El Mahalawy, Iman M. El Kholy, Samar S. Mohamed, and . 2022. Antifungal Activity of Thymol Against Some Medically Important Fungi. THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany), 18 (1), 21-31. doi:10.5455/egyjebb.20220120025332



Chicago Style

, Ghada K. Fath Allah, Adel A. El Mahalawy, Iman M. El Kholy, Samar S. Mohamed, and . "Antifungal Activity of Thymol Against Some Medically Important Fungi." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany) 18 (2022), 21-31. doi:10.5455/egyjebb.20220120025332



MLA (The Modern Language Association) Style

, Ghada K. Fath Allah, Adel A. El Mahalawy, Iman M. El Kholy, Samar S. Mohamed, and . "Antifungal Activity of Thymol Against Some Medically Important Fungi." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany) 18.1 (2022), 21-31. Print. doi:10.5455/egyjebb.20220120025332



APA (American Psychological Association) Style

, G. K. F. A., , A. A. E. M., Kholy, I. M. E., Mohamed, S. S. & (2022) Antifungal Activity of Thymol Against Some Medically Important Fungi. THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany), 18 (1), 21-31. doi:10.5455/egyjebb.20220120025332