E-ISSN 2090-0503 | ISSN 1687-7497
 
2023, Vol: 19, Issue: 2
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Original Research 


Bacteriophage and probiotic therapy in the treatment of Pseudomonas aeruginosa burn infection and their synergistic effect

Rezvan Golmoradi Zadeh, Masoumeh Hallaj Zadeh, Mohammad sholeh, sajjad Asgharzadeh, Atieh Darbandi, Parisa Abbasi Fashami, Nour Amirmozafari.

Abstract
One of the most common bacteria in nosocomial and burn infections is Pseudomonas aeruginosa. Due to the high antibiotic resistance of P. aeruginosa and the lack of other effective therapeutic agents, treating diseases caused by this bacterium could be challenging. Therefore, finding novel solutions to control and prevent highly resistant strains of P. aeruginosa is paramount. After isolation and identification of Lactobacilli with known probiotic properties such as L. acidophilus, L. paracasei, L. rhamnosus, and L. bulgaricus using PCR technique, and preparation of their corresponding phage (PAO1 Φ), probiotics and phage were used individually and in combination to treat burn infection caused by P. aeruginosa in a mouse model. The results revealed that the combination of phage with probiotics can be highly effective for treating P. aeruginosa burn infections. Our study showed that the most effective multiple cocktails of Lactobacilli for the treatment of P. aeruginosa infection, were L. rhamnosus + L. bulgaricus + L. paracasei cocktail in mixture with phage (PAO1 Φ). The study proposes an alternative method for the treatment of P. aeruginosa infections. The combination of probiotics with phage could be proposed as a new therapeutic agent for treating P. aeruginosa infections.

Key words: burn infection, Lactobacilli, phage therapy, probiotic therapy, Pseudomonas aeruginosa


 
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How to Cite this Article
Pubmed Style

Zadeh RG, Zadeh MH, sholeh M, Asgharzadeh s, Darbandi A, Fashami PA, Amirmozafari N. Bacteriophage and probiotic therapy in the treatment of Pseudomonas aeruginosa burn infection and their synergistic effect. Egypt. J. Exp. Biol. (Bot.). 2023; 19(1): 21-29. doi:10.5455/egyjebb.20221207072545

Web Style

Zadeh RG, Zadeh MH, sholeh M, Asgharzadeh s, Darbandi A, Fashami PA, Amirmozafari N. Bacteriophage and probiotic therapy in the treatment of Pseudomonas aeruginosa burn infection and their synergistic effect. https://www.egyseb.net//?mno=92279 [Access: August 15, 2023]. doi:10.5455/egyjebb.20221207072545

AMA (American Medical Association) Style

Zadeh RG, Zadeh MH, sholeh M, Asgharzadeh s, Darbandi A, Fashami PA, Amirmozafari N. Bacteriophage and probiotic therapy in the treatment of Pseudomonas aeruginosa burn infection and their synergistic effect. Egypt. J. Exp. Biol. (Bot.). 2023; 19(1): 21-29. doi:10.5455/egyjebb.20221207072545


Vancouver/ICMJE Style

Zadeh RG, Zadeh MH, sholeh M, Asgharzadeh s, Darbandi A, Fashami PA, Amirmozafari N. Bacteriophage and probiotic therapy in the treatment of Pseudomonas aeruginosa burn infection and their synergistic effect. Egypt. J. Exp. Biol. (Bot.). (2023), [cited August 15, 2023]; 19(1): 21-29. doi:10.5455/egyjebb.20221207072545


Harvard Style

Zadeh, R. G., Zadeh, . M. H., sholeh, . M., Asgharzadeh, . s., Darbandi, . A., Fashami, . P. A. & Amirmozafari, . N. (2023) Bacteriophage and probiotic therapy in the treatment of Pseudomonas aeruginosa burn infection and their synergistic effect. Egypt. J. Exp. Biol. (Bot.), 19 (1), 21-29. doi:10.5455/egyjebb.20221207072545


Turabian Style

Zadeh, Rezvan Golmoradi, Masoumeh Hallaj Zadeh, Mohammad sholeh, sajjad Asgharzadeh, Atieh Darbandi, Parisa Abbasi Fashami, and Nour Amirmozafari. 2023. Bacteriophage and probiotic therapy in the treatment of Pseudomonas aeruginosa burn infection and their synergistic effect. THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany), 19 (1), 21-29. doi:10.5455/egyjebb.20221207072545


Chicago Style

Zadeh, Rezvan Golmoradi, Masoumeh Hallaj Zadeh, Mohammad sholeh, sajjad Asgharzadeh, Atieh Darbandi, Parisa Abbasi Fashami, and Nour Amirmozafari. "Bacteriophage and probiotic therapy in the treatment of Pseudomonas aeruginosa burn infection and their synergistic effect." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany) 19 (2023), 21-29. doi:10.5455/egyjebb.20221207072545


MLA (The Modern Language Association) Style

Zadeh, Rezvan Golmoradi, Masoumeh Hallaj Zadeh, Mohammad sholeh, sajjad Asgharzadeh, Atieh Darbandi, Parisa Abbasi Fashami, and Nour Amirmozafari. "Bacteriophage and probiotic therapy in the treatment of Pseudomonas aeruginosa burn infection and their synergistic effect." THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany) 19.1 (2023), 21-29. Print. doi:10.5455/egyjebb.20221207072545


APA (American Psychological Association) Style

Zadeh, R. G., Zadeh, . M. H., sholeh, . M., Asgharzadeh, . s., Darbandi, . A., Fashami, . P. A. & Amirmozafari, . N. (2023) Bacteriophage and probiotic therapy in the treatment of Pseudomonas aeruginosa burn infection and their synergistic effect. THE EGYPTIAN JOURNAL OF EXPERIMENTAL BIOLOGY (Botany), 19 (1), 21-29. doi:10.5455/egyjebb.20221207072545


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